Summary of trials of medical therapy after acute coronary syndrome

·      Thrombolytic therapy

-        Thrombolysis improves outcomes for STEMI patients but not NSTEMI patients (GISSI-1 and ISIS-2). In GISSI-1, streptokinase reduced all-cause in-hospital mortality with a number needed to treat (NNT) of 44 for the entire cohort. In ISIS-2, streptokinase reduced vascular mortality over 5 weeks with a NNT of 36 for the en…