JAMA 1982; 247:1707-14 Background Beta blockers were commonly used in the treatment of coronary artery disease by the mid-1970s, predominately for symptomatic relief of angina. Lower quality evidence was also emerging that they reduced myocardial oxygen demand, could limit infarct size and improve survival in patients suffering from an acute myocardial infarction. National Heart, Lung, and Blood Institute (NHLBI) sponsored the beta blocker heart attack trial (
Amazing review. This was before my time and already established as settled science by the time I was a trainee, and was a part of rote practice. But boy is it revealing to have a detailed and critical walk down memory lane. Enrolled “Mean 14 days post MI”….wow….that represents current MI care at a level that rounds down to zero. Also interesting that it did not benefit the NSTEMI subgroup.
Looking forward to future entries in this hit list. I suspect it will be a who’s who of exemplars to Dr. Mandrola’s contention that evidence should have an expiry date.
Thank you very much to the authors. This book will be extremely helpful for younger cardiologists trying to build their understanding of current evidence from the ground up.
I really love this initiative!!! Many thanks to the authors for these historical much needed reviews! I hope younger doctors find their way to this trials as part of their continuous medical education. History can teach us a lot!
Amazing review. This was before my time and already established as settled science by the time I was a trainee, and was a part of rote practice. But boy is it revealing to have a detailed and critical walk down memory lane. Enrolled “Mean 14 days post MI”….wow….that represents current MI care at a level that rounds down to zero. Also interesting that it did not benefit the NSTEMI subgroup.
Looking forward to future entries in this hit list. I suspect it will be a who’s who of exemplars to Dr. Mandrola’s contention that evidence should have an expiry date.
Thank you very much to the authors. This book will be extremely helpful for younger cardiologists trying to build their understanding of current evidence from the ground up.
I really love this initiative!!! Many thanks to the authors for these historical much needed reviews! I hope younger doctors find their way to this trials as part of their continuous medical education. History can teach us a lot!