Well said. This is the first study I’m aware of in the cardiology space (and as you say, perhaps in any space) that demonstrates the difference btw surrogate markers and hard clinical outcomes.
This trial strikes fear in cardiologists for 1C’s. I know in my (turn of the century) training that I was inured with a healthy respect (and possibly even unhealthy phobia) of the entire class.
Post MI with abnormal LV function? Yeah, don’t do it. But I’ve long avoided it even in stable CAD when considering PIP for PAF. That is NOT an evidence-based position, from which I am still slowly trying to extricate myself.
Excellent summary. This may be the most important RCT ever performed. Should be reviewed and understood by every doctor.
Well said. This is the first study I’m aware of in the cardiology space (and as you say, perhaps in any space) that demonstrates the difference btw surrogate markers and hard clinical outcomes.
This trial strikes fear in cardiologists for 1C’s. I know in my (turn of the century) training that I was inured with a healthy respect (and possibly even unhealthy phobia) of the entire class.
Post MI with abnormal LV function? Yeah, don’t do it. But I’ve long avoided it even in stable CAD when considering PIP for PAF. That is NOT an evidence-based position, from which I am still slowly trying to extricate myself.