Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial
Been looking forward to this. Thanks also for focussing on the dosing issue. I was among those whose initial takeaway was “don’t use tartrate in HFrEF” so this was helpful info.
I am still biased towards using a BB with direct HFrEF evidence, although I agree that this trial was tilted by design against tartrate. Fortunately there are a couple of options, although in Canada we do not have succinate.
Been looking forward to this. Thanks also for focussing on the dosing issue. I was among those whose initial takeaway was “don’t use tartrate in HFrEF” so this was helpful info.
I am still biased towards using a BB with direct HFrEF evidence, although I agree that this trial was tilted by design against tartrate. Fortunately there are a couple of options, although in Canada we do not have succinate.
Interesting that you don't have succinate. As you mentioned, several other reasonable options though