That's a good question. To the best of our knowledge, no large scale trials directly compared them head to head. They have different side effects profiles since eplerenone has less affinity to progesterone and androgen receptors. We provided more details related to this question in our podcast "Summary and discussion of TRACE and EPHESUS" to be published Feb 19, at 5:30 am EST.
Eplerenone benefits rather robust patient, what about spironolactone?
That's a good question. To the best of our knowledge, no large scale trials directly compared them head to head. They have different side effects profiles since eplerenone has less affinity to progesterone and androgen receptors. We provided more details related to this question in our podcast "Summary and discussion of TRACE and EPHESUS" to be published Feb 19, at 5:30 am EST.