Very interesting to see that this trial included pts with “unstable” syndromes, yet only mandated DAPT for 8 weeks. And yet the 1 yr clinical secondary endpoints still favoured the DES arm (and presumably without increase in subacute stent thrombosis). This is a much shorter duration of DAPT than the current “standard DAPT” regimens esp for ACS….and even shorter than some of the “short DAPT” regimens that have been tested.
Hi Matt, this is just one of many trials we will review (and have already reviewed). It was not designed to address the questions you are raising but we have addressed those specific questions in other trials and on the podcast and will do so again in the future.
Thank you. I was commenting on these sorts of studies that do not have a true control group. I think it is very flawed not to have a control group without the treatment.
Very interesting to see that this trial included pts with “unstable” syndromes, yet only mandated DAPT for 8 weeks. And yet the 1 yr clinical secondary endpoints still favoured the DES arm (and presumably without increase in subacute stent thrombosis). This is a much shorter duration of DAPT than the current “standard DAPT” regimens esp for ACS….and even shorter than some of the “short DAPT” regimens that have been tested.
Hi Matt, this is just one of many trials we will review (and have already reviewed). It was not designed to address the questions you are raising but we have addressed those specific questions in other trials and on the podcast and will do so again in the future.
Thank you. I was commenting on these sorts of studies that do not have a true control group. I think it is very flawed not to have a control group without the treatment.
How about no stents at all. Where is the true control group. Drug eluting balloons did about as well as stents
https://www.jacc.org/doi/abs/10.1016/j.jcin.2014.09.023
But what about drug therapy, diet interventions?
In older studies there was no difference except in cases of significantly reduced left ventricular ejection fraction.
https://www.nejm.org/doi/abs/10.1056/NEJM198704163161603