The dosing comment is huge. That was a pretty large dose to get an effect. Plenty of instances even in the right pt it will be put on to have stated it’s on but not to level of trial. Any cardiology out there who could answer why though we do see EF recovery in pts on lower doses?
That's a great question. Lower dose beta-blockers may still work in certain patients. Furthermore, most patients are also taking other medications that are beneficial in patients with systolic heart failure such as angiotensin converting enzyme inhibitors and aldosterone receptor antagonists.
One should also take into consideration why a patient is not on high dose beta-blockers. Is it because the medication was never titrated up or because the patient has end stage systolic heart failure and is unable to tolerate medical therapy. The latter group is less likely to benefit.
The screening in this trial was also quite strenuous. Clinicians who have heart failure patients referred to them can't screen their patients nearly as carefully.
The dosing comment is huge. That was a pretty large dose to get an effect. Plenty of instances even in the right pt it will be put on to have stated it’s on but not to level of trial. Any cardiology out there who could answer why though we do see EF recovery in pts on lower doses?
That's a great question. Lower dose beta-blockers may still work in certain patients. Furthermore, most patients are also taking other medications that are beneficial in patients with systolic heart failure such as angiotensin converting enzyme inhibitors and aldosterone receptor antagonists.
One should also take into consideration why a patient is not on high dose beta-blockers. Is it because the medication was never titrated up or because the patient has end stage systolic heart failure and is unable to tolerate medical therapy. The latter group is less likely to benefit.
The screening in this trial was also quite strenuous. Clinicians who have heart failure patients referred to them can't screen their patients nearly as carefully.