Can someone comment on the rationale for adding stroke to the composite endpoints in these CAD trials? Obviously people who have risk of MI also have risk of stroke, but how does it help compare outcomes from PCI or CABG?
Good question!! It's because stroke is one of the complications with both procedures. For example, in the FREEDOM trial, Stroke within 30-days after the procedure/ surgery was 1.8% with CABG and 0.3% with PCI.
Just want to thank you Guys for the amazing job you are doing with the articles and podcasts. For someone, like myself, doing residency in Cardiology, finding your Substack changes and simplifies learning.
Can someone comment on the rationale for adding stroke to the composite endpoints in these CAD trials? Obviously people who have risk of MI also have risk of stroke, but how does it help compare outcomes from PCI or CABG?
Good question!! It's because stroke is one of the complications with both procedures. For example, in the FREEDOM trial, Stroke within 30-days after the procedure/ surgery was 1.8% with CABG and 0.3% with PCI.
PCI does not reduce mortality in stable disease.
PCI is not non-inferior to CABG but it was due to repeat revascularization.
You make a very good point that medical treatment is an option.
What is your opinion, should anyone (apart from maybe patients with diabetes) undergo CABG or PCI for stable symptoms?
Just want to thank you Guys for the amazing job you are doing with the articles and podcasts. For someone, like myself, doing residency in Cardiology, finding your Substack changes and simplifies learning.
Keep it up!
Greetings from Portugal!